1. Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects.

Mitra J, Guerrero EN, Hegde PM, Liachko NF, Wang H, Vasquez V, Gao J, Pandey A, Taylor JP, Kraemer BC, Wu P, Boldogh I, Garruto RM, Mitra S, Rao KS, Hegde ML.Proc Natl Acad Sci U S A. 2019 Mar 5;116(10):4696-4705. doi: 10.1073/pnas.1818415116. Epub 2019 Feb 15.PMID: 30770445

  1. Mutant FUS causes DNA ligation defects to inhibit oxidative damage repair in Amyotrophic Lateral Sclerosis.

Wang H, Guo W, Mitra J, Hegde PM, Vandoorne T, Eckelmann BJ, Mitra S, Tomkinson AE, Van Den Bosch L, Hegde ML. Nat Commun. 2018 Sep 11;9(1):3683. doi: 10.1038/s41467-018-06111-6.PMID: 30206235

  1. Pervasive Genomic Damage in Experimental Intracerebral Hemorrhage: Therapeutic Potential of a Mechanistic-Based Carbon Nanoparticle.

Dharmalingam P, Talakatta G, Mitra J, Wang H, Derry PJ, Nilewski LG, McHugh EA, Fabian RH, Mendoza K, Vasquez V, Hegde PM, Kakadiaris E, Roy T, Boldogh I, Hegde VL, Mitra S, Tour JM, Kent TA, Hegde ML.ACS Nano. 2020 Mar 24;14(3):2827-2846. doi: 10.1021/acsnano.9b05821. Epub 2020 Feb 21.PMID: 32049495

  1. TDP-43/FUS in motor neuron disease: Complexity and challenges.

Guerrero EN, Wang H, Mitra J, Hegde PM, Stowell SE, Liachko NF, Kraemer BC, Garruto RM, Rao KS, Hegde ML. Prog Neurobiol. 2016 Oct-Nov;145-146:78-97. doi: 10.1016/j.pneurobio.2016.09.004. Epub 2016 Sep 28.PMID: 27693252

  1. Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.

Guerrero EN, Mitra J, Wang H, Rangaswamy S, Hegde PM, Basu P, Rao KS, Hegde ML.Hum Mol Genet. 2019 Sep 15;28(18):3161-3162. doi: 10.1093/hmg/ddz141.PMID: 31504503

  1. DNA Damage and Repair Deficiency in ALS/FTD-Associated Neurodegeneration: From Molecular Mechanisms to Therapeutic Implication.

Wang H, Kodavati M, Britz GW, Hegde ML. Front Mol Neurosci. 2021 Dec 16;14:784361. doi: 10.3389/fnmol.2021.784361. eCollection 2021.PMID: 34975400

  1. Altered Mitochondrial Dynamics in Motor Neuron Disease: An Emerging Perspective.

Kodavati M, Wang H, Hegde ML.Cells. 2020 Apr 24;9(4):1065. doi: 10.3390/cells9041065.PMID: 32344665

  1. A multi-faceted genotoxic network of alpha-synuclein in the nucleus and mitochondria of dopaminergic neurons in Parkinson’s disease: Emerging concepts and challenges.

Vasquez V, Mitra J, Wang H, Hegde PM, Rao KS, Hegde ML.Prog Neurobiol. 2020 Feb;185:101729. doi: 10.1016/j.pneurobio.2019.101729. Epub 2019 Dec 18.PMID: 31863801

  1. Revisiting the intersection of amyloid, pathologically modified tau and iron in Alzheimer’s disease from a ferroptosis perspective.

Derry PJ, Hegde ML, Jackson GR, Kayed R, Tour JM, Tsai AL, Kent TA.Prog Neurobiol. 2020 Jan;184:101716. doi: 10.1016/j.pneurobio.2019.101716. Epub 2019 Oct 8.PMID: 31604111

  1. A Commentary on TDP-43 and DNA Damage Response in Amyotrophic Lateral Sclerosis.

Mitra J, Hegde ML.J Exp Neurosci. 2019 Oct 10;13:1179069519880166. doi: 10.1177/1179069519880166. eCollection 2019.PMID: 31656396

  1. RT2PCR array screening reveals distinct perturbations in DNA damage response signaling in FUS-associated motor neuron disease.

Wang H, Rangaswamy S, Kodavati M, Mitra J, Guo W, Guerrero EN, Van Den Bosch L, Hegde ML.Mol Brain. 2019 Dec 4;12(1):103. doi: 10.1186/s13041-019-0526-4.PMID: 31801573

  1. Loss of endosomal recycling factor RAB11 coupled with complex regulation of MAPK/ERK/AKT signaling in postmortem spinal cord specimens of sporadic amyotrophic lateral sclerosis patients.

Mitra J, Hegde PM, Hegde ML.Mol Brain. 2019 Jun 13;12(1):55. doi: 10.1186/s13041-019-0475-y.PMID: 31196199

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